Middle Ages Research Articles

The Memory-CD8+-T-Cell Response to Conserved Influenza Virus Epitopes in Mice Is Not Influenced by Time Since Previous Infection

To protect older adults against influenza A virus (IAV) infection, innovative strategies are imperative to overcome the decrease in protective immune response with age. One approach involves the boosting of CD8+ T cells at middle age that were previously induced by natural infection. At this stage, the immune system is still fit. Given the high conservation of T-cell epitopes within internal viral proteins, such a response may confer lasting protection against evolving influenza strains at older age, also reducing the high number of influenza immunizations currently required. However, at the time of vaccination, some individuals may have been more recently exposed to IAV than others, which could affect the T-cell response. We therefore investigated the fundamental principle of how the interval between the last infection and booster immunization during middle age influences the CD8+ T-cell response. To model this, female mice were infected at either 6 or 9 months of age and subsequently received a heterosubtypic infection booster at middle age (12 months). Before the booster infection, 6-month-primed mice displayed lower IAV-specific CD8+ T-cell responses in the spleen and lung than 9-month-primed mice. Both groups were better protected against the subsequent heterosubtypic booster infection compared to naïve mice. Notably, despite the different CD8+ T-cell levels between the 6-month- and 9-month-primed mice, we observed comparable responses after booster infection, based on IFNγ responses, and IAV-specific T-cell frequencies and repertoire diversity. Lung-derived CD8+ T cells of 6- and 9-month-primed mice expressed similar levels of tissue-resident memory-T-cell markers 30 days post booster infection. These data suggest that the IAV-specific CD8+ T-cell response after boosting is not influenced by the time post priming.

Exploring access-based consumption in last-mile logistics: a customer foresight study

Purpose Due to e-commerce growth, technological advancements and environmental concerns, developing a more nuanced service portfolio has become a critical issue for last-mile logistics service providers. Concurrently, consumers are adopting new modes of consumption. This paper aims to investigate the potential for last-mile logistics service providers to act as intermediaries in access-based consumption and to revitalise their service offerings through product-service systems – a pioneering strategy not executed in the market yet. Design/methodology/approach This strategic customer foresight study uses a quantitative survey of 1,000 respondents and an online focus group comprising 10 early adopter consumers to investigate emerging last-mile service models. Potential service concepts were identified through the survey, and two distinct concepts were subsequently selected for evaluation and co-development within the focus group. The research was conducted in partnership with an SME logistics company in Finland. Findings The consumers expressed selective interest in access-based consumption related to the proposed offering of essential household goods. Young adults and consumers in early middle age living in the city centre emerged as the most potential user groups. Economic reasons and short-term needs were the primary motivations for adopting access-based consumption. Practical implications The study showed that engaging consumers in a customer foresight process is viable for SMEs innovating their offerings and demonstrates how the process works in practice. Originality/value Documented cases of customer integration into foresight processes are rare in earlier research, and this paper extends the knowledge base through a multidisciplinary examination of future consumer behaviour in the last-mile logistics domain. The paper also expands the limited literature on the role of logistics in access-based consumption.

The Prevalence and Determinants of Hesitancy for Regular COVID-19 Vaccination among Primary Healthcare Patients with Asthma or COPD in Greece: A Cross-Sectional Study

The emergence of novel coronavirus mutations and signs of the waning immunity provided by COVID-19 vaccines underscore the importance of regular vaccination. This study aimed to investigate the prevalence of regular COVID-19 vaccination hesitancy and the factors that influence it among patients with asthma or chronic obstructive pulmonary disease (COPD) who visited primary care centers. The cross-sectional study was conducted in six primary healthcare centers in Crete, Greece (October–December 2023). Participants completed a questionnaire, which included questions about socio-demographic characteristics, health status, previous COVID-19 booster vaccination, attitudes, and beliefs about COVID-19 vaccination. Multivariate logistic regression was used to identify the factors that influenced vaccine hesitancy. Of the 264 participants, 65% exhibited hesitancy towards COVID-19 booster vaccination. Female gender, middle age, lower educational attainment, depression diagnosis, concerns about vaccine side effects, lack of confidence in vaccine efficacy, and reliance on media information were positively associated to vaccine hesitancy. Conversely, those having a cardiovascular disease or type 2 diabetes, those generally adhering to the recommendations of the treating physician, and those having previously received the flu vaccine or more than three COVID-19 vaccine doses were positively associated with regular COVID-19 vaccinations. Consequently, our findings could help develop strategies that could potentially reduce regular vaccination hesitancy among patients with asthma or COPD.

Magnetic and GPR Data Modelling via Multiscale Methods in San Pietro in Crapolla Abbey, Massa Lubrense (Naples)

ABSTRACTWe performed magnetic and GPR measurements to image the buried ruins of the Middle Age abbey San Pietro in Crapolla, on the Sorrento‐Amalfi Coast (Massa Lubrense, Southern Italy). The site represents an important religious location, which is nowadays partially buried along the cliff. An integrated study was necessary to map the buried structures and address the archaeological excavation. For this reason, we carried out the surveys on two main grids in order to reconstruct the structures of the abbey and of its related church. The magnetic data were filtered through the discrete wavelet transform (DWT) and then transformed to total gradient maps. The obtained maps were interpreted with depth from extreme points (DEXP) imaging method to assess the horizontal and depth positions of the top. The GPR data were processed and time‐depth converted. Results from the integrated interpretation of these data suggest the possible presence of different vaulted rooms and an elongated structure at 0.3‐m depth from ground surface. This latter is interpretable in terms of perimetral and internal walls of the abbey and its church. These outcomes were crucial to successfully address archaeological excavations, which targeted one of the modelled areas and unearthed a wall at the predicted depths.

The blossoming of classical topomythopoiesis

A cursory glance at Italian Renaissance gardens reveals that they are populated by the beings of classical mythology. Venus, Apollo, Pegasus, Hercules, … are frozen figures in stone that have come to characterise the iconography of the verdant villas they inhabit. Were they included as devices to narrate myths? Or, did they serve as intricate symbolic ensembles to be decoded like the garden artefacts of the Hypnerotomachi poliphili? I visit these questions in this article (as part of a series on the history of gardens that evoke Greco-Roman myths) by investigating the expression and reception of Renaissance topomythopoeic gardens through the eyes of a contemporary chronicler of gardens, Bartholomeo Taegio (1520–1573). Extracts from his dialogue, La Villa (1559), are used throughout to frame a general discussion of Renaissance topomythopoiesis: the rhetoric of the locus amoenus and Parnassus, the appropriation of statues, and Neoplatonic reception and conception. Whereas the gods survived the Christian Middle Ages as beings that animated the ekphrastic language of landscape (and seldom adorned emblematic fountains) there emerged in sixteenth-century Italy a trend to concretise their presence. Yet, as Taegio’s account shows, not everyone encountered these as stories to be read or hidden codes to be deciphered.

Phenotypic Expression and Outcomes in Patients with the p.Arg301Gln GLA Variant in Anderson–Fabry Disease

The p.Arg301Gln variant in the α -galactosidase A gene (GLA) has been poorly described in the literature. The few reports show controversial information, with both classical and nonclassical Anderson–Fabry Disease (AFD) presentation patterns. The aim of this study was to analyze the penetrance, clinical phenotype, and biochemical profile of an international cohort of patients carrying the p.Arg301Gln genetic variant in the GLA gene. This was an observational, international, and retrospective cohort case series study of patients carrying the p.Arg301Gln variant in the GLA gene associated with AFD disease. Forty-nine p.Arg301Gln GLA carriers, 41% male, were analyzed. The penetrance was 63% in the entire cohort and 1.5 times higher in men. The mean age of symptoms onset was 41 years; compared to women, men presented symptoms earlier and with a shorter delay to diagnosis. The typical clinical triad—cornea verticillate, neuropathic pain, and angiokeratomas—affected only 20% of the cohort, with no differences between genders. During follow-up, almost 20% of the patients presented some type of nonfatal cardiovascular and renal event (stroke, need for dialysis, heart failure, and arrhythmias requiring intracardiac devices), predominantly affecting men. Residual levels were the most common finding of α-GAL A enzyme activity, only a few women had a normal level; a small proportion of men had undetectable levels. The incidence of combined outcomes including all causes of death was 33%, and the cumulative incidence of all-cause mortality was 9% at the follow-up. Patients carrying the p.Arg301Gln GLA variant have a high penetrance, with predominantly cardiorenal involvement and clinical onset of the disease in middle age. Only a small proportion showed the classic clinical presentation of AFD. As in other X-linked diseases, males were more affected by severe cardiovascular and renal events. This genotype–phenotype correlation could be useful from a practical clinical point of view and for future decision making.

Middle Jurassic to Early Cretaceous orogenesis in the Klamath Mountains Province (Northern California–southern Oregon, USA) occurred by tectonic switching: Insights from detrital zircon U-Pb geochronology of the Condrey Mountain schist

The Klamath Mountains Province of Northern California and southern Oregon, USA, consists of generally east-dipping terranes assembled via Paleozoic to Mesozoic subduction along the western margin of North America. The Klamath Mountains Province more than doubled in mass from Middle Jurassic to Early Cretaceous time, due to alternating episodes of extension (e.g., rifting and formation of the Josephine ophiolite) and shortening (e.g., Siskiyou and Nevadan events). However, the tectonic mechanisms driving this profound Mesozoic growth of the Klamath Mountains Province are poorly understood. In this paper, we show that formation of the Condrey Mountain schist (CMS) of the central Klamath Mountains Province spanned this critical time period and use the archive contained within the CMS as a key to deciphering the Mesozoic tectonics of the Klamath Mountains Province. Igneous samples from the outer CMS subunit yield U-Pb zircon ages of ca. 175–170 Ma, which reflect volcanic protolith eruptive timing. One detrital sample from the same subunit contains abundant (~54% of zircon grains analyzed) Middle Jurassic ages with Paleozoic and Proterozoic grains comprising the remainder and yields a maximum depositional age (MDA) of ca. 170 Ma. These ages, in the context of lithologic and thermochronologic relations, suggest that outer CMS protoliths accumulated in an outboard rift basin and subsequently underthrust the Klamath Mountains Province during the Late Jurassic Nevadan orogeny. Five samples of the chiefly metasedimentary inner CMS yield MDAs ranging from 160 Ma to 130 Ma, with younger ages corresponding to deeper structural levels. Such inverted age zonation is common in subduction complexes and, considering existing K-Ar ages, suggests that the inner CMS was assembled by progressive underplating over a >10 m.y. timespan. Despite this age zonation, age spectra derived from structurally shallow and deep portions of the inner CMS closely overlap those derived from the oldest section of the Franciscan subduction complex (South Fork Mountain schist). These relations suggest that the inner CMS is a composite of South Fork Mountain schist slices that were sequentially underplated beneath the Klamath Mountains Province. The age, inboard position, and structural position (i.e., the CMS resides directly beneath Jurassic arc assemblages with no intervening mantle) of the CMS suggest that these rocks were emplaced during one or more previously unrecognized episodes of shallow-angle subduction restricted to the Klamath Mountains Province. Furthermore, emplacement of the deepest portions of the CMS corresponds with the ca. 136 Ma termination of magmatism in the Klamath Mountains Province, which we relate to the disruption of asthenospheric flow during slab shallowing. The timing of shallow-angle subduction shortly precedes that of the westward translation of the Klamath Mountains Province relative to correlative rocks in the northern Sierra Nevada Range, which suggests that subduction dynamics were responsible for relocating the Klamath Mountains Province from the arc to the forearc. In aggregate, the above relations require at least three distinct phases of extension and/or rifting, each followed by an episode of shallow-angle underthrusting. The dynamic upper-plate deformation envisioned here is best interpreted in the context of tectonic switching, whereby slab steepening and trench retreat alternate with slab shallowing due to recurrent subduction of buoyant oceanic features.

Behind the waterfall - Interdisciplinary results from Holley Shelter and their implications for understanding human behavioral patterns at the end of the Middle Stone Age in southern Africa

Holley Shelter is a Middle (MSA) and Later Stone Age (LSA) site in KwaZulu-Natal, South Africa. The rock shelter is located at the intersection of three ecosystems, in a strip of the Savanna Biome between the Grassland and Indian Ocean Coastal Belt Biomes. Initial excavations in the 1950s by Gordon Cramb yielded large amounts of unifacial points and splintered pieces, as well as organic remains associated with MSA occupations. Our comparative techno-typological evaluation of this material in 2015 suggested the occupations may date to early MIS 3. We then initiated new excavations at the site using modern field methods and controlled sampling for lithic and organic material. Following the initial round of interdisciplinary analysis, we herein report the first absolute ages for Holley Shelter, a detailed technological analysis of new lithic material from the uppermost MSA layers at the site, and a preliminary study of the associated faunal remains. A set of 12 14C dates place these occupations within a constricted chronological period dated to ∼36,000–34,000 cal. BP that overlaps with the so-called ‘final MSA’. The hornfels-dominated lithic assemblages are characterized by diverse core technologies oriented toward the production of laminar products, which include bladelets and abundant splintered pieces. The zooarchaeological analysis documents an emphasis on open grasslands that provided the bulk of the animal prey exploited by the inhabitants of the shelter, with a preference for medium-sized antelopes. Three bone retouchers, a rare occurrence in southern African MSA contexts, were identified in the faunal assemblage. The archaeological deposits at Holley Shelter reflect short-term, potentially seasonal, and specialized occupations that could be influenced by its ecological position. The archaeological material exhibits marked discrepancies with other well-dated final MSA assemblages such as those from Sibhudu, Umbeli Belli, Sibebe and Border Cave. This illustrates considerable variability and a complex spatio-temporal patterning of behavioral adaptations and cultural traditions at the end of the MSA in southern Africa.

EVOLUTION OF CONCESSION OPERATIONS

In todayʼs dynamic world, it is important to understand the roots and evolution of key econo­mic and legal mechanisms. The article is devoted to a detailed analysis and description of conces­sion operations during various historical stages: from ancient times, the Middle Ages, stages of development in the 19th and 20th centuries, ana­ly­sis of its modern trends in the 21st century. The relevance of the research lies in the in-depth disclosure of the mechanisms underlying conces­sion operations and their impact on the econo­mic, social and cultural development of the society. Studying the history of concessions will help specialists and researchers to better assess current trends and predict future developments in this field. The aim of the article is to characterize the key evolutionary stages of con­cession operations in order to understand their essence and critical features, based on the hypothesis that they have transformed from simple agreements to complex multi-stakeholder contracts for various public services and goods. The research metho­dology is based on an integ­rated approach, which includes historical, com­pa­rative and analytical research methods. As a result, the research is provided a holistic view of the evolution of con­cession arrangements, their significance and role in the formation of econo­mic relations at various stages of historical development.

Association between Screen Time and Sociodemographic Factors, Physical Activity, and BMI among Children in Six European Countries (Feel4Diabetes): A Cross-Sectional Study

Screen time among children in most European countries is notably high and is influenced by various sociodemographic and other factors. Our study aimed to explore the associations between parents’ sociodemographic characteristics, socioeconomic status, body mass index (BMI), physical activity, risk status for type 2 diabetes, and their children’s BMI, physical activity, and screen time. The data were sourced from the 2016 Feel4Diabetes study, involving 12,280 parents and 12,211 children aged 6–9 years (average age 8.21 years) in a cross-sectional study design. We used a logistic regression model to identify potential factors associated with children’s screen time. The results showed that mothers with tertiary education (OR = 0.64; 95%CI = 0.49–0.82; p < 0.001), the middle age group (45–54 years) (OR = 0.81 95%CI = 0.66–0.98; p = 0.033), and families with higher incomes (middle–OR = 0.85; 95%CI = 0.75–0.97; p = 0.014; high–OR = 0.8; 95%CI = 0.69–0.93; p = 0.003) were associated with a decreased chance of children spending more than 2 h/day in front of the screen. In contrast, maternal overweight/obesity (OR = 1.15; 95%CI = 1.03–1.29; p = 0.013) and lower physical activity in children were linked to an increased likelihood of more than 2 h of screen time per day. Our findings suggest that targeted interventions should be developed to mitigate excessive screen time, particularly focusing on low-income families and mothers with low educational levels.

Gene pool preservation across time and space In Mongolian-speaking Oirats.

The Oirats are a group of Mongolian-speaking peoples residing in Russia, China, and Mongolia, who speak Oirat dialects of the Mongolian language. Migrations of nomadic ethnopolitical formations of the Oirats across the Eurasian Steppe during the Late Middle Ages/early Modern times resulted in a wide geographic spread of Oirat ethnic groups from present-day northwestern China in East Asia to the Lower Volga region in Eastern Europe. In this study, we generate new genome-wide and mitochondrial DNA data for present-day Oirat-speaking populations from Kalmykia in Eastern Europe, Western Mongolia, and the Xinjiang region of China, as well as Issyk-Kul Sart-Kalmaks from Central Asia, and historically related ethnic groups from Altai, Tuva, and Northern Mongolia to study the genetic structure and history of the Oirats. Despite their spatial and temporal separation, small current population census, both the Kalmyks of Eastern Europe and the Oirats of Western Mongolia in East Asia are characterized by strong genetic similarity, high effective population size, and low levels of interpopulation structure. This contrasts the fine genetic structure observed today at a smaller geographic scale in traditionally sedentary populations, and is conditioned by high mobility and marriage practices (traditional strict exogamy) in nomadic groups. Conversely, the genetic profile of the Issyk-Kul Sart-Kalmaks suggests a distinct source(s) of genetic ancestry, along with indications of isolation and genetic drift compared to other Oirats. Our results also show that there was limited gene flow between the ancestors of the Oirats and the Altaians during the late Middle Ages. Source of the yurt image: https://www.vecteezy.com/free-vector/yurt .

Self-Rated Health in Middle Age and Risk of Hospitalizations and Death: Recurrent Event Analysis of the ARIC Study.

Self-rated health is a simple measure that may identify individuals who are at a higher risk for hospitalization or death. To quantify the association between a single measure of self-rated health and future risk of recurrent hospitalizations or death. Atherosclerosis Risk in Communities (ARIC) study, a community-based prospective cohort study of middle-aged men and women with follow-up beginning from 1987 to 1989. We quantified the associations between initial self-rated health with risk of recurrent hospitalizations and of death using a recurrent events survival model that allowed for dependency between the rates of hospitalization and hazards of death, adjusted for demographic and clinical factors. Of the 14,937 ARIC cohort individuals with available self-rated health and covariate information, 34% of individuals reported "excellent" health, 47% "good," 16% "fair," and 3% "poor" at study baseline. After a median follow-up of 27.7years, 1955 (39%), 3569 (51%), 1626 (67%), and 402 (83%) individuals with "excellent," "good," "fair," and "poor" health, respectively, had died. After adjusting for demographic factors and medical history, a less favorable self-rated health status was associated with increased rates of hospitalization and death. As compared to those reporting "excellent" health, adults with "good," "fair," and "poor" health had 1.22 (1.07 to 1.40), 2.01 (1.63 to 2.47), and 3.13 (2.39 to 4.09) times the rate of hospitalizations, respectively. The hazards of death also increased with worsening categories of self-rated health, with "good," "fair," and "poor" health individuals experiencing 1.30 (1.12 to 1.51), 2.15 (1.71 to 2.69), and 3.40 (2.54 to 4.56) times the hazard of death compared to "excellent," respectively. Even after adjusting for demographic and clinical factors, having a less favorable response on a single measure of self-rated health taken in middle age is a potent marker of future hospitalizations and death.

Variation in Mesenchymal KITL/SCF and IGF1 Expression at Middle Age Underlies Steady-State Hematopoietic Stem Cell Aging

Intrinsic molecular programs and extrinsic factors including pro-inflammatory molecules are understood to regulate hematopoietic aging. This is based on foundational studies using genetic perturbation to evaluate causality. However, individual organisms exhibit natural variation in hematopoietic aging phenotypes and the molecular basis of this heterogeneity is poorly understood. Here, we generated individual single cell transcriptomic profiles of hematopoietic and non-hematopoietic cell types in five young adult and nine middle-aged C57BL/6J female mice, providing a web-accessible transcriptomic resource for the field. Among all assessed cell types, hematopoietic stem cells (HSCs) exhibited the greatest phenotypic variation in expansion among individual middle-aged mice. We computationally pooled samples to define modules representing the molecular signatures of middle-aged HSCs and interrogated which extrinsic regulatory cell types and factors would predict variance in these signatures between individual middle-aged mice. Decline in signaling mediated by ADIPOQ, KITL and IGF1 from mesenchymal stromal cells (MSCs) was predicted to have the greatest transcriptional impact on middle-aged HSCs, as opposed to signaling mediated by endothelial cells or mature hematopoietic cell types. In individual middle-aged mice, lower expression of Kitl and Igf1 in MSCs highly correlated with reduced lymphoid lineage commitment of HSCs and increased signatures of differentiation-inactive HSCs. These signatures were independent of expression of aging-associated pro-inflammatory cytokines including IL1β, IL6, TNFα and RANTES. In sum, we find that Kitl and Igf1 expression are co-regulated and variable between individual mice at middle age and expression of these factors is predictive of HSC activation and lymphoid commitment independently of inflammation.

Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.

Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans. The present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). We hypothesized that racial discrimination assessed during middle age would predict increases in these serum biomarkers as the participants aged into their 60s. Our findings indicate that exposure to various forms of racial discrimination during a person's 40s and early 50s predicts an 11-year increase in both serum p-tau181 and NfL. Racial discrimination was not associated with subsequent levels of GFAP. These findings suggest that racial discrimination in midlife may contribute to increased AD pathology and neurodegeneration later in life. A 17-year longitudinal study of Black Americans. Assessments of change in serum p-tau181, neurofilament light, and glial fibrillary acidic protein. Exposure to racial discrimination during middle age predicted increases in p-tau181 and neurofilament light. Education was positively related to both p-tau181 and exposure to racial discrimination.

Camilla's traces: Movement as an analytical key to literary history

AbstractIn this article, we develop a framework for the analysis of ‘movement’ in literary texts. We focus on characters, translation and transmission, thereby going beyond, on the one hand, a stylistic analysis of individual passages, and, on the other hand, the linear enchainment of scenes and summaries underlying much of the narratological discussions around movement, speed and pace. We will develop this framework through a discussion of the character Camilla in Vergil's Aeneid: Book XI, Gavin Douglas's Eneados (1513) and John Dryden's Aeneis (1698). Both the version stylistically close to Vergil (Dryden) and the one that is stylistically looser (Douglas) allow for a discussion of movement that takes the principle beyond a primary concern with style. In a final step, we move to the contemporary example of Ursula Le Guin's Lavinia (2008) in order to investigate how ‘movement’ translates from the epic to the novel. Movement, as we shall show, can be analysed as movement of plot, movement of thought, and movement of figure in narrative. The framework that we propose allows for the principled discussion of transgeneric transfer of narratives, here between epic and novel, as well as the comparison of texts from different moments of literary history between the Middle Ages, the Early Modern period and the present day.

A Critical Inventory and Associated Chronology of the Middle Stone Age and Later Stone Age in Northwest Africa

A Critical Inventory and Associated Chronology of the Middle Stone Age and Later Stone Age in Northwest Africa

The biostratigraphy and palaeobiogeography of Cambrian and Ordovician acritarchs and chitinozoa from the Simeh-Kuh, NW Damghan City, the Alborz Mountains, northern Iran

A study in Simeh-Kuh, northern Iran, focuses on Ordovician strata, documenting acritarchs and chitinozoa, which is vital for understanding ancient environments. It aims to chronostratigraphically calibrate using palaeontological data, including brachiopods, trilobites, and graptolites. Ninety-three surface samples were collected and analysed, yielding a rich collection of 117 morphotypes, including 59 acritarch species and 58 chitinozoan species. Eight acritarch assemblage biozones (A-H) and fourteen chitinozoan biozones (1-14) were established. Biozones A-F indicate Late Cambrian to Middle Ordovician ages in the Lashkarak Formation, while biozones G-H in the Ghelli Formation indicate Late Ordovician. Eremochitina brevis-Linochitina pissotensis biozones suggest late Floian to late Darriwilian ages, and Belonechitina robusta-Armoricochitina nigerica biozones support a Late Ordovician age. These findings place the Alborz Mountains in the North Gondwana Domain during the Ordovician. Palynomorphs with a Thermal Alteration Index of 4.0-4.5 indicate overmature organic matter in lower Palaeozoic deposits, potentially linked to the Ordovician metamorphic event in the southern Caspian Sea. Additionally, four new species were identified: Cyathochitina sp. A, Tanuchitina hosseini-nezhadi sp. nov., Dactylofusa kazzazii sp. nov., and Inflatarium alborzensis sp. nov.

Social determinants of respiratory health from birth: still of concern in the 21st century?

Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often trivialised. Adverse exposures pre-conception, antenatally and in early childhood have lifetime impacts on respiratory health. For the most part, lung function tracks from the pre-school years at least into late middle age, and airflow obstruction is associated not merely with poor respiratory outcomes but also early all-cause morbidity and mortality. Much would be preventable if social determinants of adverse outcomes were to be addressed. This review presents the perspectives of paediatricians from many different contexts, both high and low income, including Europe, the Americas, Australasia, India, Africa and China. It should be noted that there are islands of poverty within even the highest income settings and, conversely, opulent areas in even the most deprived countries. The heaviest burden of any adverse effects falls on those of the lowest socioeconomic status. Themes include passive exposure to tobacco smoke and indoor and outdoor pollution, across the entire developmental course, and lack of access even to simple affordable medications, let alone the new biologicals. Commonly, disease outcomes are worse in resource-poor areas. Both within and between countries there are avoidable gross disparities in outcomes. Climate change is also bearing down hardest on the poorest children. This review highlights the need for vigorous advocacy for children to improve lifelong health. It also highlights that there are ongoing culturally sensitive interventions to address social determinants of disease which are already benefiting children.

Learning from medieval Italy: urban sustainability concepts from the heritage of hydraulic infrastructures. The cases of Venice, Siena and Bologna

PurposeFaced with the growing need to find new viable water supply models for urban areas, this article studies and maps the strategies and identifies the key criteria of sustainable development present in pioneering water supply systems in the medieval period. The main aim is to determine which of its innovative principles could be applied in present-day cities.Design/methodology/approachFrom a methodological perspective, two types of cases were established, such as water supply models for human consumption and pre-industrial hydraulic systems, all of which are located in Italy. For the first group, the cases of Venice and Siena were analysed, while for the second, in the context of the cities along the Aemilian Way, the case of Bologna was selected.FindingsFive key criteria resulted from the analysis of the cases: exploitation, self-sufficiency, maintenance, rationalisation and reuse. The said concepts were defined and contextualised within the framework of the Sustainable Development Goals.Originality/valueThe Middle Ages were a historic moment in technological reinvention, before the development of modern systems of sanitation. With very limited resources, these traditional systems focused on rational use and deep cultural and geographical knowledge. This is why its recognition is of great importance today, in a time full of instabilities, with a view to the work that needs to be done for the development of more sustainable communities.

The socioeconomic epidemiology of inherited retinal diseases in Portugal

BackgroundInherited retinal diseases (IRDs) are a group of rare degenerative disorders of the retina that can lead to blindness from birth to late middle age. Knowing the target population and its resources is essential to better plan support measures. The aim of this study was to evaluate the socioeconomic characteristics of regions in Portugal where IRD patients reside to inform the planning of vision aid and rehabilitation intervention measures.ResultsThis study included 1082 patients from 973 families, aged 3 to 92 years, with a mean age of 44.8 ± 18.1 years. Patients living with an IRD were identified in 190 of the 308 municipalities. According to this study, the estimated IRD prevalence in Portugal was 10.4 per 100,000 inhabitants, and by municipalities, it ranged from 0 to 131.2 per 100,000 inhabitants. Overall, regions with a higher prevalence of IRD have a lower population density (r=-0.371, p < 0.001), a higher illiteracy rate (r = 0.404, p < 0.001) and an overall older population (r = 0.475, p < 0.001). Additionally, there is a lower proportion of doctor per capita (r = 0.350, p < 0.001), higher social security pensions beneficiaries (r = 0.439, p < 0.001), worse water quality for human consumption (r=-0.194, p = 0.008), fewer audiences at the cinema (r=-0.315, p < 0.001) and lower proportion of foreign guests in tourist accommodations (r=-0.287, p < 0.001).ConclusionThe number of identified patients with IRD varied between regions. Using data from national statistics (PORDATA), we observed differences in socioeconomic characteristics between regions. Multiple targeted aid strategies can be developed to ensure that all IRD patients are granted full clinical and socioeconomic support.